Do You Believe Fish Oil Has Cardiovascular Benefits?

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Questions about the cardiovascular benefits of omega-3s and the high-dose eicosapentaenoic acid (EPA) product icosapentethyl (Vascepa) have resurfaced with the STRENGTH study recently presented at the American Heart Association (AHA) virtual conference.

The STRENGTH study showed no benefit on cardiovascular event rates of a high dose combination of EPA and docosahexaenoic acid (DHA) in a new branded product (Epanova).

This is in contrast to the very positive results of last year’s REDUCE-IT study, which showed a relative risk reduction of 25% for serious adverse cardiovascular events with the high-dose, purified EPA product icosapentethyl.

Some of the suggested explanations for the discrepancies include the fact that different placebos were used in the two studies, with some suggesting that mineral oil is an active placebo. The REDUCE-IT investigators deny this; Their explanation is that DHA can counteract some of the EPA’s benefits.

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Quote this: Do you think fish oil has cardiovascular benefits? – Medscape – November 18, 2020.

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