Study shows omega-3 fatty acid supplementation is linked to less inflammation and flare-ups in lupus

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New research suggests that omega-3 fatty acid supplements may help improve outcomes in people with lupus. The study identified thresholds for two measurements – an omega-3 highly unsaturated fat (HUFA) level of over 40% and an omega-3 index (O3I) of over 10% – that will one day be used as nutritional goals for people with lupus could.

The results are based on data from previous studies in female mice fed varying doses of docosahexaenoic acid (DHA), a type of omega-3 fatty acid found in certain types of seafood and algae. The tissue and red blood cell omega-3 fatty acid levels of the mice were then measured using omega-3 HUFA and O3I values. The data confirmed that higher and higher supplement doses of DHA were associated with higher and higher omega-3 HUFA and O3I levels. And higher omega-3 HUFA and / or O31 levels were linked to a decrease in several markers of inflammation and the progression of autoimmune diseases.

Lead study author Kathryn Wierenga, a PhD student and researcher at Michigan State University, added, “We believe that measuring patients’ omega-3 status is critical to establishing an effective personalized supplement regimen to reduce inflammation – and to reduce possibly inflammation-related lupus flare-ups. ”. We hope that our preclinical results will advance the design of human studies to test this hypothesis. “

This latest research is a continuation of research Wierenga began in 2019 as part of the Lupus Foundation of America (LFA) Gina M. Finzi Memorial Student Summer Fellowship (Finzi) program. Your Finzi Prize also led to another recent study investigating the effects of an omega-3 supplement on animals fed a Western diet.

LFA prides itself on supporting the next generation of lupus researchers and cutting-edge research. Learn more about the Finzi Student Fellowship and the LFA’s commitment to improving research.

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