Marine Omega-3 Fatty Acid Possible Additional Treatment Option for Patients with BPD

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Marine omega-3s improved symptoms of borderline personality disorder, according to a meta-analysis published in the Journal of Clinical Psychiatry.

Improvements were particularly pronounced in behavioral disorders and affective dysregulation.

Source: Adobe Stock

“Several randomized controlled trials (RCTs) have investigated the effects of marine omega 3 [polyunsaturated fatty acid] Supplement in the treatment of various psychiatric disorders ” Dominika M. KaraszewskaBSc, from the Department of Psychiatry at the University of Amsterdam in the Netherlands, and colleagues wrote. “The effects seem to be greatest with major depression [ADHD] and aggressive behavior. Meta-analyzes of RCTs in MDD suggest a clinically relevant effect that led to the inclusion of marine omega-3 [polyunsaturated fatty acids] in MDD treatment guidelines. “

Because of this growing evidence in the MDD area, several RCTs evaluated polyunsaturated marine omega-3s in BPD; To the knowledge of the researchers, however, a meta-analysis has to be carried out on these studies. They wanted to close this research gap via the current meta-analysis by collecting estimates of the effectiveness of omega-3 fatty acids in BPD, and they distinguished a priori affective, impulsive and cognitively-perceptible symptom domains. They used BPD and omega-3-related terms to search four databases with no publication date limitation, and included five studies describing four RCTs that looked at the effects of omega-3s in 137 patients BPD or behavior related to BPD were tested. In addition, the researchers collected data on intervention dose, duration, and BPD scale values ​​using a pre-controlled data extraction form.

The results of the meta-analysis with random effects showed that omega-3 fatty acids had an overall significantly decreasing effect on the severity of BPD symptoms, with a standardized mean difference (SDM) of 0.54 (95% CI, 0.91-0 , 17) and no heterogeneity. The researchers observed significant effects on affect dysregulation (SDM = 0.74; 95% CI, 1.21-0.27) and impulse behavior (SDM = 0.45; 95% CI, 0.84-0.059) according to an a Priori differentiation of relevant symptom domains. The effects on cognitive-perceptual symptoms did not reach the threshold of significance.

“Marine omega-3s could be presented as an (additional) treatment option for BPD patients in a shared decision-making context,” wrote Karaszewska and colleagues. “As with all supplementation measures, it is important to emphasize that they are not an alternative to a healthy diet, lifestyle and are not free from side effects, although side effects are generally considered manageable. Clinically relevant effects are to be expected in particular on impulsivity and affective symptom domains. “

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