If you are taking aspirin and this medication, speak to your doctor now


Taking low doses of aspirin is a frequent daily treatment for some people because of its blood-thinning properties, which can help reduce the risk of a heart attack or stroke. However, if you are one of the many who take a daily dose alongside other pills, you may want to schedule a chat with your doctor. This is because a new study recently published in JAMA Internal Medicine found that taking aspirin with another specific type of medication may increase your health risk. Read on to see which drugs to avoid mixing and to learn more about bad combinations, read on, if you take Tylenol with it, your liver is at risk, experts say.


To answer a hypothesis about the use of specific blood thinners in combination with aspirin, University of Michigan researchers examined data on a cohort of 3,280 patients who had been prescribed a new class of direct oral anticoagulants (DOAC), including apixaban, dabigatran, edoxaban and rivaroxaban. Research showed that a third of patients also took aspirin daily when they had no other reason to take a daily dose, such as a recent heart attack or surgery such as valve replacement.

The results also showed that those who took both drugs saw an increased health risk without the potential benefits. “The patients on combination therapy had more bleeding events, but no fewer blood clots.” Jordan Schaefer, MD, the study’s lead author and assistant professor of internal medicine and hematologist at Michigan Medicine, the University of Michigan’s academic medical center, said in a statement.


The researchers suggested that some patients might still benefit from taking both drugs, including those who recently had a heart attack or had major heart surgery. But those taking a DOAC to reduce their risk of stroke or pulmonary embolism without a clear reason for taking aspirin should beware of the potentially risky combination, especially since most doctors may not know their patients are because of the The fact that this is the case cannot be treated over-the-counter (OTC) medicine.

“It is important that patients ask their doctors whether they should take aspirin if they are prescribed a direct oral anticoagulant,” Schäfer concluded in the statement. For more information on what could also increase your health risks, see If you’re taking this drug, you’re more likely to get a blood clot.

elderly man sitting alone in his kitchen taking pillsSuccess Seisa / iStock

While the benefits of daily aspirin therapy have been shown in the past, some medical experts warn that it is not for everyone. “Our guidelines clearly indicate that aspirin may be useful for some people to prevent another or second heart attack.” Eduardo SanchezMD, chief medical officer for prevention for the American Heart Association, told Healthline. “The decision to add aspirin as a therapy should, however, be made in consultation with a doctor.”

“Only selected patients – those who are 40 to 70 years old and have other risk factors for cardiovascular disease such as obesity, diabetes, blood cholesterol, high blood pressure, or smoking – can be taken as daily low-dose aspirin as first-line prevention [cardiovascular disease]”Said Sanchez.

Picture of the bottle of omega-3 fish oil capsules pouring into hand.iStock

But it’s not just DOACs that can cause complications when taken with aspirin. Researchers have found that nonsteroidal anti-inflammatory drugs (NSAID), a type of drug including ibuprofen that has antiplatelet properties, can have potentially dangerous interactions with fish oil supplements. Taken together, there is a “moderate risk” that the combination “will thin your blood and one of the possible side effects will be increased bleeding time,” explains Jessica Nouhavandi, PharmD, senior pharmacist and founder of the online pharmacy Honeybee Health.

This means that all drugs in the NSAID group, including aspirin and naproxen, can interact negatively with fish oil. For more information on dangerous drug mixes, see If you take these 2 OTC drugs together, you put your liver at risk.


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